Brief Answer:
Mitochondrial processes affected by different substances.

Detailed Answer:
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Mitochondrial Parkinson's disease refers to Parkinson's disease that may be caused by substances that affect mitochondrial processes such MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).

MPP accumulates in mitochondria and interferes with the function of complex I of the respiratory chain. A chemical resemblance between MPTP and some herbicides and pesticides suggested that an MPTP-like environmental toxin might be a cause of Parkinson disease, but no specific agent has been identified. Nonetheless, mitochondrial complex I activity is reduced in Parkinson disease, suggesting a common pathway with MPTP-induced parkinsonism.

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