Brief Answer:
There are not benefits of this adjunctive therapy.

Detailed Answer:
Hi dear user
I have gone through your question.
I can understand your concern.

Anastrozole is an aromatase inhibitor. It works by lowering blood estradiol concentrations.

Most men think of estrogen as exclusively a female hormone, but men also produce it. In fact, testosterone is the precursor of estradiol, an estrogen and the primary female sex hormone. Testosterone is converted into estradiol via the aromatase enzyme.

Because testosterone can be converted into estradiol, taking testosterone via testosterone replacement therapy (TRT) can potentially elevate estrogen levels.
Fortunately, most men on standard TRT dosages do not experience high estradiol levels.

The Endocrine Society does not recommend for or against any treatments that lower estradiol levels.
Anyway,Some physicians do treat men on TRT with high estradiol levels by co-administering anastroloze with TRT at 0.25 mg per day or 0.5 mg every other day.
Anastrozole comes in the form of a pill and is taken orally. It inhibits the ability of the aromatase enzyme to convert testosterone to estrogen. Thus, it lowers the level of circulating estradiol quite effectively.

Anastrozole is actually FDA-approved for the treatment of breast cancer in women after surgery.
As such, its use in men on testosterone replacement therapy is considered to be off-labeled.

While there is currently not enough data and/or information to know what is the optimal estradiol range in men, low estradiol levels are evidently not good. As such, taking anastrozole in the absence of clinically diagnosed high estradiol levels along with associated symptoms (gynecomastia and edema) is likely counterproductive for men on testosterone therapy.

Hope I have clarified your doubts. If you have any further queries, please feel free to ask. I would be happy to help.
Thank you for using HCM.
Wish you good health.

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