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What Is The Treatment For Choice For CLL?
Question: For first line CLL therapy, PCR may be preferred over FCR or FR because
A. pentostain trends to cause less myelosuppressions that fludarabine
B. patients are more likely to become refractory to fludarabinethan to pentostatin
C. rituximab and penostatin target the same receptors on B cells
D. pentostain is a purine analog whereas fludarabine ia a pyrimidine analog
Among other characteristics Patient LRwas diagnosed with CLL because he had
A. lymphocytes positive fo CD5 and negative for CD 23
B. sustained lymphocytosis of 14.8 X 109 cells/L not explained by other disorders
C. immature lymphocytes in his blood smear
D. <10% of tumor cell in G0 stage of the cell cycle
What agents are currently considered the treatment of choice for first-line therapy of CLL?
A. pentostain trends to cause less myelosuppressions that fludarabine
B. patients are more likely to become refractory to fludarabinethan to pentostatin
C. rituximab and penostatin target the same receptors on B cells
D. pentostain is a purine analog whereas fludarabine ia a pyrimidine analog
Among other characteristics Patient LRwas diagnosed with CLL because he had
A. lymphocytes positive fo CD5 and negative for CD 23
B. sustained lymphocytosis of 14.8 X 109 cells/L not explained by other disorders
C. immature lymphocytes in his blood smear
D. <10% of tumor cell in G0 stage of the cell cycle
What agents are currently considered the treatment of choice for first-line therapy of CLL?
Brief Answer:
rituximab
Detailed Answer:
Hi
For first line CLL therapy, PCR may be preferred over FCR or FR because pentostain trends to cause less myelosuppressions that fludarabine.
Patient was diagnosed with CLL because lymphocytes positive fo CD5 and negative for CD 23.
First line therapy of CLL include rituximab, alemtuzumab and ofatumumab.
Regards
DR De
rituximab
Detailed Answer:
Hi
For first line CLL therapy, PCR may be preferred over FCR or FR because pentostain trends to cause less myelosuppressions that fludarabine.
Patient was diagnosed with CLL because lymphocytes positive fo CD5 and negative for CD 23.
First line therapy of CLL include rituximab, alemtuzumab and ofatumumab.
Regards
DR De
Above answer was peer-reviewed by :
Dr. Shanthi.E
I understand the answer you selected. I too selected C for this answer but it was wrong. Can you give further clarification as to why this is correct
Brief Answer:
severe myelosuppression caused by fludarabine
Detailed Answer:
Hi
For the first question my answer is A that is pentostain trends to cause less myelosuppressions that fludarabine because fludarabine causes severe myelosuppression and may cause severe infection and febrile neutropenia after chemotherapy.
For the second question the answer should be B that is sustained lymphocytosis of 14.8 X 109 cells/L not explained by other disorders.
CLL is CD5 and CD 23 positive and mature lymphocytes are seen in blood smear.
Regards
DR De
severe myelosuppression caused by fludarabine
Detailed Answer:
Hi
For the first question my answer is A that is pentostain trends to cause less myelosuppressions that fludarabine because fludarabine causes severe myelosuppression and may cause severe infection and febrile neutropenia after chemotherapy.
For the second question the answer should be B that is sustained lymphocytosis of 14.8 X 109 cells/L not explained by other disorders.
CLL is CD5 and CD 23 positive and mature lymphocytes are seen in blood smear.
Regards
DR De
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Above answer was peer-reviewed by :
Dr. Yogesh D
Answered by
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