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What Medicines Could Interfere When On Paroxetine?

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Posted on Thu, 6 Mar 2014
Question: I am on ten milligram of paroxetine. what medicines could interfere? I currently take atenolol,amlodipine, clonidine and aspirin.
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Answered by Dr. Srikanth Reddy (55 minutes later)
Brief Answer: No major drug interaction Detailed Answer: Hello, Thanks for choosing health care magic for posting your query. I have gone through your question in detail and I can understand what you are going through. Paroxetine isnmetabolized in the liver and the predominant enzyme involved is CYP2D6. None of the medicines that you have stated have any serious ineraction with the paoxetine and you may take them together. The drugs with serious interaction are phenelzine, selegilline, isocarboxazide, pimozide, thioridazine.. From my personal.experience paroxetine is safe drug and can be comfortably taken with no major drug interaction. The only two issues with paroxetine are 1. It causes sedation. Hence taken at night time. 2. You should always avoiding stopping it suddenly as it has anticholinergic action and hence the withdrawal symptoms. Hope I am able to answer your concerns. If you have any further query, I would be glad to help you. If not, you may close the discussion and if possible you may rate the answer for me, so that I get a good feedback. In future if you wish to contact me directly, you can use the below mentioned link: bit.ly/dr-srikanth-reddy Wish you good health, Kind regards Dr. Srikanth Reddy M.D.
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Above answer was peer-reviewed by : Dr. Shanthi.E
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Dr. Srikanth Reddy

Psychiatrist

Practicing since :2007

Answered : 2770 Questions

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What Medicines Could Interfere When On Paroxetine?

Brief Answer: No major drug interaction Detailed Answer: Hello, Thanks for choosing health care magic for posting your query. I have gone through your question in detail and I can understand what you are going through. Paroxetine isnmetabolized in the liver and the predominant enzyme involved is CYP2D6. None of the medicines that you have stated have any serious ineraction with the paoxetine and you may take them together. The drugs with serious interaction are phenelzine, selegilline, isocarboxazide, pimozide, thioridazine.. From my personal.experience paroxetine is safe drug and can be comfortably taken with no major drug interaction. The only two issues with paroxetine are 1. It causes sedation. Hence taken at night time. 2. You should always avoiding stopping it suddenly as it has anticholinergic action and hence the withdrawal symptoms. Hope I am able to answer your concerns. If you have any further query, I would be glad to help you. If not, you may close the discussion and if possible you may rate the answer for me, so that I get a good feedback. In future if you wish to contact me directly, you can use the below mentioned link: bit.ly/dr-srikanth-reddy Wish you good health, Kind regards Dr. Srikanth Reddy M.D.