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Why Does Zanidip Causes Ankle Swelling?

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Posted on Fri, 2 Jan 2015
Question: Is there an alterative to zanidip that does not make your ankles swell?
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Answered by Dr. Tushar Kanti Biswas (38 minutes later)
Brief Answer:
ZANIDIP-ankle swelling

Detailed Answer:
Hi,

Thank you for your query. I can understand your concerns.
ZANIDIP( Lercanidipine hydrochloride) is a dihydropyridine (DHP) calcium channel blocker and is a common drug for hypertension. Mild ankle swelling is also quite common, particularly with dihydropyridine calcium-channel blockers and is often cosmetic only and occurs due to dilatation of pre-capillary arteriolar sphincter. Degree of ankle swelling may vary with different drugs (alternative as you are asking) of the same class but swelling is supposed to be less with Lercanidipine ,a relatively newer generation drug in this group.
If ankle swelling is troublesome you have to switch over to some other class of anti-hypertensive altogether e.g. angiotensin convertase inhibitors (ACEI) or Angiotensin II receptor blockers (ARBs).






Regards

Dr. T.K. Biswas M.D. XXXXXXX
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Above answer was peer-reviewed by : Dr. Yogesh D
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Answered by
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Dr. Tushar Kanti Biswas

Internal Medicine Specialist

Practicing since :1975

Answered : 1920 Questions

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Why Does Zanidip Causes Ankle Swelling?

Brief Answer: ZANIDIP-ankle swelling Detailed Answer: Hi, Thank you for your query. I can understand your concerns. ZANIDIP( Lercanidipine hydrochloride) is a dihydropyridine (DHP) calcium channel blocker and is a common drug for hypertension. Mild ankle swelling is also quite common, particularly with dihydropyridine calcium-channel blockers and is often cosmetic only and occurs due to dilatation of pre-capillary arteriolar sphincter. Degree of ankle swelling may vary with different drugs (alternative as you are asking) of the same class but swelling is supposed to be less with Lercanidipine ,a relatively newer generation drug in this group. If ankle swelling is troublesome you have to switch over to some other class of anti-hypertensive altogether e.g. angiotensin convertase inhibitors (ACEI) or Angiotensin II receptor blockers (ARBs). Regards Dr. T.K. Biswas M.D. XXXXXXX