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Will Primolut-N Taken After Conception Have Adverse Effects On The Fetus?

Posted on Wed, 3 Feb 2016

Question: I had my last menstural period on 9.11.2015. I didnt had period till 19.12.2015. Doctor had done upt and beta hcg test . Both were negative. Then doctor put me on primolut N 5 mg thrice a day for 5 days. I consumed 14 tablets. But i didnt had periods. I again did my pregnancy test and found it to be positive on 5.1.2015. In usg g sac was seen and it is saying that pregnancy is of 5weeks and 2 days. She is also saying that primolut is category x drug at the other time she is saying that that period of 20 to 25 dec is safe when i took the drug. She is also confused. Usg report says that i m 5 weeks preg and no ca is seen. Can any one please suggest. Will it be fatal or not

Answered by Dr. Deepti Verma (46 minutes later)

Brief Answer:
Do not worry

Detailed Answer:
Hi dear,
I have gone through your question and understand your concerns.
Primolut N is norethisterone which is pregnancy category D drug.
It means that it is generally not recommended in pregnancy, because there us increased risk of adverse effects on the fetus have been seen in women taking this drug in pregnancy.
However, the adverse effects on the fetus are not 100% and not seen in all the patients.
Moreover, if your ultrasound on 5/1/16 showed a pregnancy of 5 weeks2 days, that means you might have conceived around 13-14/12/15. So you took the primolut after conception.
But taking primolut is not an indication for termination of pregnancy, so you can continue with the pregnancy.
Iwill suggest you to get a detailed anomaly ultrasound at 18-20 weeks of pregnancy to rule out any congenital anomalies.
I suggest you to not to take stress.
I have seen many patients who took primolut in pregnancy, having healthy pregnancy and
Hope you found the answer helpful.
Please do get back for further queries.
Wishing you good health.
Regards
Dr Deepti Verma
OBGYN

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Deepti Verma (23 minutes later)

18 weeks maens in april. Wont it be too late. Physical abnormality will be diagnosed by usg but what if any mental abnormality is there. Any test to decide on it. Doctor is saying that it is null and void so it wont effect. This one is precious for me ut at the same time i cannot handle any abnormality in child. Please suggest

Answered by Dr. Deepti Verma (1 minute later)

Brief Answer:
No central nervous system anomalies

Detailed Answer:
Hi dear,
Do not be stressed out.
Primolut N is known to cause genital and urinary tract anomalies in the fetus, if at all it causes, which is rare.
It is not known to cause any brain anomaly or deranged mental development of the fetus.
Please be calm, and do not panic.
18-20 weeks is never too late for termination of pregnancy, in case any major abnormality is detected.
Let the fetus has its chances, so I suggest you to continue with the pregnancy.
There are very minor chances of congenital anomaly in the fetus.
I am always here to help you.
You can get back to me anytime by asking a direct question to me on the health care magic portal.
Regards
Dr Deepti Verma
OBGYN
Maternal and fetal medicine specialist

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Deepti Verma (4 hours later)

I have read that primolut N can also cause masculisation of female foetus. Is it detectable from ultra sound after 20 weeks. What does it mean. 20 weeks means almost 5 months will it b safe if i have to go for MTP then. How to assure that my foetus is good

Answered by Dr. Deepti Verma (3 hours later)

Brief Answer:
MTP safe till 20 weeks of gestation

Detailed Answer:
Hi dear,
Genitourinary anomalies include masculinisation of female fetus.
It is an extremely rare anomaly.
It is difficult to detect by ultrasound, however can be detected by a fetal medicine specialist.
It is safe to get MTP done till 20 weeks of pregnancy.
Regards
Dr Deepti Verma

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar