Brief Answer: Yes. Detailed Answer: Hello, Welcome to XXXXXXX Thanks for your query. Anti Hypertensives(Blood pressure medicines) are known to produce such symptoms. Blood pressure drugs belonging to ACE inhibitors group like enalapril is known to produce drug non productive cough which may be troublesome to the patient. In such conditions when the patient is not able to tolerate the cough then that group of anti hypertensive drugs needs to be stopped and other groups of drugs can be started in such patients. Calcium channel blockers drugs like Amlodipine produces swelling of the ankles by reducing the venous blood flow. This can be improved by elevation of the leg while sitting and lying. This elevation helps in return of the venous blood. Good control of blood pressure can take care of fatigue. Consult your doctor to rule out if this are side effects of the medicine. If so your doctor will help you by making changes in you blood pressure medicines. Hope the answer helps you. Let me know if there are any clarifications. Regards.

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