Brief Answer:
Reports of omeprazole to cause erectile dysfunction

Detailed Answer:
Hello and welcome to Ask A Doctor service.

I have reviewed your query and here is my advice.

There are some reports that Omeprazole can cause erectile dysfunction. Also omeprazole inhibits the cytochrome enzymes and sidenafil is metabolized by some of them. So theoretically there maybe accumulation of sildenafil.

But I could not find clinically relevant drug interactions between the two medicines and these can be combined. To be safe, take lower dose of sildenafil.

Dr Vaishalee

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