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Hi..i M.dr XXXXXXX Gurjar 28 Year Mbbs,diagnosed With Ig A
Question: hi..i m.dr XXXXXXX gurjar 28 year mbbs,diagnosed with ig a nephropathy 2 month ago..my renal biopsyshws 30%sclerosis in glomerulrus and 22% firbovascular cresent formation...s.creat1.6..serum k 4.2 proetunira 3+..i m given endoxan(cyclophosphamide ) 500g at ebery 15 days...for 6 doses. XXXXXXX one doses for every 3 mont for 3 doswes..so.is it correct schedule for young patient like me? want to know the exact dosage shedule of endoxan for young patient as it has potential side effect of azospermia..kindaly give suggestions..
hi..i m.dr XXXXXXX gurjar 28 year mbbs,diagnosed with ig a nephropathy 2 month ago..my renal biopsyshws 30%sclerosis in glomerulrus and 22% firbovascular cresent formation...s.creat1.6..serum k 4.2 proetunira 3+..i m given endoxan(cyclophosphamide ) 500g at ebery 15 days...for 6 doses. XXXXXXX one doses for every 3 mont for 3 doswes..so.is it correct schedule for young patient like me? want to know the exact dosage shedule of endoxan for young patient as it has potential side effect of azospermia..kindaly give suggestions..
Brief Answer:
Hi- endoxan is ok
Detailed Answer:
Hi,
Endoxan ( cyclophosphamide ) is the best treatment in cresentic nephritis.
So the way to treat IgA nephropathy is with steroid ( wysolone) 1 mg /kg for I month then taper and endoxan if rapid creatinine progression is there or crescents are there.
monitor serum creatinine, urine routine, urine spot P/C Ratio monthly.
infertility will occur if endoxan cumulative dose exceeds 200mg/kg, so giving three to 5 grams does not cause infertility routinely.
also once you complete the induction phase of 3 months of endoxan then you can shift to Azathioprine as tab 2mg/Kg/day it is less toxic
The kidney biopsy report does show some chronicity. So we need to carefully monitor for next few months.
best wishes
Hi- endoxan is ok
Detailed Answer:
Hi,
Endoxan ( cyclophosphamide ) is the best treatment in cresentic nephritis.
So the way to treat IgA nephropathy is with steroid ( wysolone) 1 mg /kg for I month then taper and endoxan if rapid creatinine progression is there or crescents are there.
monitor serum creatinine, urine routine, urine spot P/C Ratio monthly.
infertility will occur if endoxan cumulative dose exceeds 200mg/kg, so giving three to 5 grams does not cause infertility routinely.
also once you complete the induction phase of 3 months of endoxan then you can shift to Azathioprine as tab 2mg/Kg/day it is less toxic
The kidney biopsy report does show some chronicity. So we need to carefully monitor for next few months.
best wishes
Above answer was peer-reviewed by :
Dr. Remy Koshy
sir..in my treatment doses of endoxan is 500.mg per 15 days for 6 doses. XXXXXXX 500 mg omce in 3 month for reamining 3 doses..it is corrct shedule for me..?bcz othwr nephrologist said me it shud b 500 mg per month for maximum 6 doses..so wht is better for young patient like me? and also plz give idea about induction phase of endoxan...
Brief Answer:
Hi
Detailed Answer:
dont worry doses are ok.
but you can change to azuran at 3 months. just see cbc before next dose every 15 days to document TLC more than 5000
best wishes
Hi
Detailed Answer:
dont worry doses are ok.
but you can change to azuran at 3 months. just see cbc before next dose every 15 days to document TLC more than 5000
best wishes
Note: For further queries related to kidney problems and comprehensive renal care, talk to a Nephrologist. Click here to Book a Consultation.
Above answer was peer-reviewed by :
Dr. Vaishalee Punj
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