Hello, My question is regarding depression and IBS. I have had v. mild sx s of IBS in the past, and these were controlled with the prokinetic agent tegaserod (Zelnorm) which is now off the market due to the incidence of stroke/heart disease in older females. Last year I had ECT (12 treatments) and 2-3 weeks post, I had severe constipation and progressively IBS. Under the guidance of a gastroenterologist I have taken Resotran 4mg (double dose) for months with no improvement. In addition, with the management of my psychiatrist, I stopped the cymbalta, and we substituted sertraline-but no improvement. Do you think that the IBS and the depression are related? Any suggestions?