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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Are There Any Alternate Medication For Sotalol?

I was told there is a new drug I could replace my sotalol with, have my energy back. I would go in hospital for three days to be monitored. What is the name of the drug and what do you think of it. I have atrial fibrillation, had two ablutions. I always have to be converted back in rhythm. Marilyn
Tue, 4 Nov 2014
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Internal Medicine Specialist 's  Response
Hello Marilyn,

The recent medicine for prevention of atrial fibrillation is Dofetilide. It is a class III antiarrhythmic agent, marketed as Tikosyn by Pfizer. It is available in the United States as 125, 250, and 500 µg capsules.
It is used for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter.
Loss of energy and tiredness are not listed as side effects but may produce headache, dizziness and nausea.
Torsades de pointes is its most serious side effect. The incidence of torsades de pointes is dose-related.The risk of inducing torsades de pointes can be decreased by taking precautions when initiating therapy, such as hospitalizing individuals for a minimum of three days for serial creatinine measurement, continuous telemetry monitoring and availability of cardiac resuscitation.
Since you had two unsuccessful radioablations and the af has to be cardioverted each time, I think Dofetilide is worth s try.
Best wishes,
Dr Noble Zachariah
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Are There Any Alternate Medication For Sotalol?

Hello Marilyn, The recent medicine for prevention of atrial fibrillation is Dofetilide. It is a class III antiarrhythmic agent, marketed as Tikosyn by Pfizer. It is available in the United States as 125, 250, and 500 µg capsules. It is used for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter. Loss of energy and tiredness are not listed as side effects but may produce headache, dizziness and nausea. Torsades de pointes is its most serious side effect. The incidence of torsades de pointes is dose-related.The risk of inducing torsades de pointes can be decreased by taking precautions when initiating therapy, such as hospitalizing individuals for a minimum of three days for serial creatinine measurement, continuous telemetry monitoring and availability of cardiac resuscitation. Since you had two unsuccessful radioablations and the af has to be cardioverted each time, I think Dofetilide is worth s try. Best wishes, Dr Noble Zachariah