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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Are There Any Interactions Between Lyrica, Tramadol And Diazepam?

I take prescribed lyrica 50mg with 1 x tramadol and 2 mgs diazepam and find them having a knock out effect, which is not pleasant, and wonder which drug it is with the diazepam that does this. I am presently being weaned off diazepam and take the others for chronic neuritis
Fri, 27 Apr 2018
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General & Family Physician 's  Response
Hello and Welcome to ‘Ask A Doctor’ service.
I have reviewed your query and here is my advice.

Yes, if taken together they may cause harmful interactions.

Taking opioid medication like Tramadol together with Diazepam that also causes central nervous system depression can lead to serious side effects including respiratory distress, coma, and even death.

Taking Tramadol and Diazepam along with Lyrica may increase side effects such as excessive drowsiness, confusion, difficulty concentrating and motor coordination which may result in falls and injuries.

Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications.

Hope I could clarify your concerns.
A feedback is appreciated.
Regards,
Dr. Mohammed Taher Ali
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Are There Any Interactions Between Lyrica, Tramadol And Diazepam?

Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. Yes, if taken together they may cause harmful interactions. Taking opioid medication like Tramadol together with Diazepam that also causes central nervous system depression can lead to serious side effects including respiratory distress, coma, and even death. Taking Tramadol and Diazepam along with Lyrica may increase side effects such as excessive drowsiness, confusion, difficulty concentrating and motor coordination which may result in falls and injuries. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Hope I could clarify your concerns. A feedback is appreciated. Regards, Dr. Mohammed Taher Ali