Hello aarin85 , greetings from healthcaremagic.com I am Dr Sourav Chakraborty and i will be helping you with your query. As i can see from your details your mother is taking the following, 1) telekast/montelucast , seroflo and combimist inhalers for her Asthma 2) AKT4 for her tuberculosis ( i assume she is suffering from tuberculosis of lung , as you have not provided further details ) and 3) esam and losar-h for her high blood pressure Now the answer to your question IS IT A SIDE EFFECT OF MEDICINE? is a MAY BE and despite having two medications her blood pressure is still high and either she needs revision of dosage/ increase in dose of the currently administered drug or i believe we need to introduce another medication to control her blood pressure, but before doing so the etiology/causative factor for such needs to be investigated. As currently your mother is having quite a lot of medication , i believe you need to elaborately discuss with your doctor about the possible side effects she might encounter. i will discuss about very limited few but significant interactions, 1) Isoniazid , one of the drug in AKT4 for her tuberculosis will increase the level or effect of amlodipine in the drug esam by affecting hepatic/intestinal enzyme metabolism. Needs monitoring . 2) Rifampin , another one of the drug in AKT4 for her tuberculosis will decrease the level or effect of amlodipine in the drug esam by affecting hepatic/intestinal enzyme metabolism. Needs monitoring 3) Rifampin, again will decrease the level or effect of losartan in losar-h by affecting hepatic enzyme metabolism. Needs monitoring. Currently your primary physician has a better clinical knowledge of your mother and i will suggest you to interact with him more and listen to his/her suggestion. These kind of interactions are unavoidable yet can be controlled in a multi drug regimen like as of your mother. Hope i have been lucid in my approach . Take care