hi arunsthapathy, I have read your question, Without physical examination and medical history , I cannot conclude anything here, but mostly you may be suffering with hemorrhoids,constipation,and mostly anal fissures due to passage of hard stools, I suggest you to take plenty of water , with fibrous food like oat meals and non-spicy items, A natural procedure in which take a tub , with luke-warm water and salt and sitting in it would give a temporary relief. The Drugs you have mentioned should work well for you , and i Suggest you to discontinue Zentel As it is not related anywhere and its dosage is once in 6 months as well. If yout problem persists , I suggest you to consult a gastroenterologist immediately. Wishing you a good health, DR.G.Gayatri devi.