can prolonged use of "flagyl" and "Levaquin" (both were prescribed multiple times - due to Diverticulitis) cause Periphal Neuropathy. My husband suffers severe leg and foot numbness, tingling, and very painful. after 5 months of testing various specialty doctors they thought it was Gillian barre - but found colon cancer. it was removed at stage 1. We are very greatful, but the leg and foot pain, tingling and numbness stlill persists. SEVERELY. I saw an ad on TV that said prolonged use of Levaquin can cause this.