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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can I Switch From Isosorbide Dinitrate And Isosorbide Mononitrate For The Treatment Of Heart Attack?

my father had a heart attack three months ago and was giving prescription isosorbide dinitrate 10mg but than was switched to isosorbide mononitrate 60mg. what is the difference and what are the dangers if he doesn t take them for a weak. he ran out of the medications and is waiting for his new refill from VA. Thank you for your attention.
Mon, 16 Dec 2013
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General & Family Physician,  's  Response
Hi. Isosorbide mononitrate (ISMN) is the active metabolite (product of) of Isosorbide dinitrate (ISDN) and is primarily used in the management of a condition called chronic stable angina which your father might be suffering from. These are basically vasodilators (means they dilate the blood vessels and increases the blood flow thereby preventing lack of blood in that particular area). ISMN is usually preferred for your father condition. So switching from ISMN to ISDN is not harmfull. Its not safe to miss the doses for 1 week. If he has missed a dose then he can take them as soon as he remembers it but remember that he wont pop more pills to compensate the missed pills, its not safe and can lead to overdose symptoms. I advice you to consult cardiologist and get a opinion. But please make sure to have stock of these tablets and not to miss them. All the best and take care
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Can I Switch From Isosorbide Dinitrate And Isosorbide Mononitrate For The Treatment Of Heart Attack?

Hi. Isosorbide mononitrate (ISMN) is the active metabolite (product of) of Isosorbide dinitrate (ISDN) and is primarily used in the management of a condition called chronic stable angina which your father might be suffering from. These are basically vasodilators (means they dilate the blood vessels and increases the blood flow thereby preventing lack of blood in that particular area). ISMN is usually preferred for your father condition. So switching from ISMN to ISDN is not harmfull. Its not safe to miss the doses for 1 week. If he has missed a dose then he can take them as soon as he remembers it but remember that he wont pop more pills to compensate the missed pills, its not safe and can lead to overdose symptoms. I advice you to consult cardiologist and get a opinion. But please make sure to have stock of these tablets and not to miss them. All the best and take care