yes!!! if you have jut started the ortho tricylen yes! very much! just becuz your body is not used to having that chemical in your body! Every woman is different and since you are changing something in your body your body has to adjust to whats happening to it. Although if you have been taking it for quit sometime and you have never had moodswings before, you may want to go to your local doctor to see if your pregant justto be sure