Dear lady, I really appreciate your concern for your husband but there are a few things that you need to consider Firstly, there is no direct effect of RA on kidneys. It does not damage the kidney per se. However, RA is a spectrum of autoimmune diseases where your own antibodies have become your enemy. These antibodies keep causing some amount of vasculitis(inflammation of the blood vessels in body). The vasculitis can also indirectly affect your kidneys to varying extents. Also, pts of RA also are prescribed NSAIDS which also contribute to kidney damage. The best approach would be to get certain investigations done to assess the present state of your kidneys 1. USG to see your kidney architecture 2. Urinanalysis including 24 hr urine protein excretion to asses any initial damage that has begun 3. Finally, a DTPA scan to objectively asses the functionality of each of your kidneys. In my opinion, with these three investigations, we will be able to clearly decipher if you can be a donor or not Feel free to post any further queries or get back with test results. Thanks