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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can Blood Group In Parents Makes Any Difference For Fetus Abnormalities?

Hi! I marriage with my first cousin. Someone tells me that there is chances of abnormality is cousin marriages. If both have contrast (means not same) blood group then abnormality can be reduced by taken an injection available in market for that purpose. I want to know the exact answer that whether its true or not?
Mon, 25 Aug 2014
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General & Family Physician,  's  Response
Thanks for using healthcaremagic.I understand your question.
Brief answer:Not really.
Detailed answer:
Blood groups(ABO) doesn't play role in causing harm to the fetus,rather rhesus(Rh)factor---a protein on red blood cell (which may be negative or positive).This Rh disease abnormality may happen only when mother is Rh negative and father is Rh positive.
For example,consider the mother's blood group is A-ve(Rh negative) father's is O+ve(Rh positive) and the fetus(male) has inherited Rh factor(Rh+ve) from the father.In this setting,when small amount of baby's blood crosses the barrier and gets contacted with the mother's blood by chance,antibodies will be produced against that Rh factor,which causes destruction of red blood cells in the fetus and death eventually.Usually first pregnancy is spared because of low concentration of antibodies.Anti-D(Rho immunoglobulin injections prophylactically givenfor Rh negative pregnant women to prevent this alloimmunization.However consanguineous marriage is not recommended scientifically, which may result in genetic abnormalities(diseases) in future generations.Hope this information helps you.If any questions,happy to answer you.Take care.
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Note: For detailed guidance on genetic screening consult a genetics specialist
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Can Blood Group In Parents Makes Any Difference For Fetus Abnormalities?

Thanks for using healthcaremagic.I understand your question. Brief answer:Not really. Detailed answer: Blood groups(ABO) doesn t play role in causing harm to the fetus,rather rhesus(Rh)factor---a protein on red blood cell (which may be negative or positive).This Rh disease abnormality may happen only when mother is Rh negative and father is Rh positive. For example,consider the mother s blood group is A-ve(Rh negative) father s is O+ve(Rh positive) and the fetus(male) has inherited Rh factor(Rh+ve) from the father.In this setting,when small amount of baby s blood crosses the barrier and gets contacted with the mother s blood by chance,antibodies will be produced against that Rh factor,which causes destruction of red blood cells in the fetus and death eventually.Usually first pregnancy is spared because of low concentration of antibodies.Anti-D(Rho immunoglobulin injections prophylactically givenfor Rh negative pregnant women to prevent this alloimmunization.However consanguineous marriage is not recommended scientifically, which may result in genetic abnormalities(diseases) in future generations.Hope this information helps you.If any questions,happy to answer you.Take care.