Hello, thank you for using health care magic. There are several potentially harmful substances in paints, depending on the type of paint being used. The most well-known toxic substances in paint are volatile organic compounds, known as VOCs. VOCs are a byproduct of either solids, liquids or a combination of both in paint. When paint is applied, the byproduct is released into the atmosphere in the form of a gas (paint fumes). VOCs are generally at a higher concentration when indoors . Yes paint fumes can impact respiratory system when exposed to during long term. But since your patient is already having respiratory disease, there is a possibility of exacerbation of her symtoms. Therefore I would advise you to avoid her from being exposed to paint fumes. Other short term adverse effects of paint fumes include: Irritation of the eyes, nose, throat or and/or respiratory tract, visual disturbances, headaches, loss of coordination, nausea, lightheadedness dizziness, allergic skin reaction and fatigue.