Hi, PEG (polyethylene glycol) with electrolyte is a laxative that works by drawing large amounts of water into the colon. It is is used to clean out the intestines before certain bowel exam procedures such as colonoscopy. This effect results in watery bowel movements. Usual side effects includes Nausea, bloating, or feelings of fullness in the stomach/abdomen are very common. Stomach/abdominal cramps, vomiting, and anal irritation occur less often. A very serious allergic reaction like blood in vomiting or diarrhea is rare and this drug can be taken safely without any reason to worry. PEG 3350 with electrolytes and PPIs or H2Is do not show any interactions as per review of medical literature.