Hello, I have gone through your query and understand your concern. Pazopanib have potential to cause high blood pressure. It should be used with caution in hypertensive patients and heart patients. She must monitor her Blood pressure daily while on Pazopanib. Pazopanib can affect the functioning of the heart, especially the heart rhythm. This can develop into a serious abnormal heart rhythm known as torsades de pointes. In most patients, this does not have any symptoms, but some people may experience shortness of breath or an irregular heartbeat if affected. Thus her heart function should be monitored with an ECG before starting and during treatment with pazopanib. There is also a risk of developing a blood clot in a vein (DVT or pulmonary embolism) or a blood clot in an artery (which could cause a heart attack or stroke) while taking pazopanib. Thus consult your treating physician either to increase the dose of anti hypertensives or switch over to other anti cancer drugs. Hope this helps. Please write back for further queries. Wishing you good health.