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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Do Encorate Chorno / Valparin Effect The Fertility Or Cause Problems To Conceive ?

Hello Doctor, hope you re doing good. I am epileptic patient since 12 yrs back, but now im fine for the past 2 years, I am taking encorate chrono 500mg and rivotril 0.5, both tabs, morning once and after dinner 1 tab. I want advice from you as iam married for the past 4 years and my wife hasn t conceived, we are trying our best level but I want to know does this encorate chorno/valparin effects ? pls help us Regards, Mohamed jaffer, Dar es salaam Tanzania
Tue, 11 Jun 2019
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General & Family Physician,  's  Response
Hello,

The reproductive system can be affected by epilepsy and it's medications, and pituitary hormone abnormalities can be encountered in patients with epilepsy.

The mechanism underlying this effect has a close relationship with the alteration of signals in the hypothalamic-pituitary axis.

The pituitary gland is responsible for releasing sex hormones, including FSH and LH, whereas the hypothalamus indirectly controls these hormones by releasing the gonadotropin-releasing hormone that targets receptors in the pituitary gland.

Valparin treatment does not alter the sex hormone levels in patients with partial and generalized epilepsy. On the other hand, monotherapy negatively affects sperm count, sperm morphology, motility, and sperm functionality.

Furthermore, a decrease in the number of functional sperm is associated with an increased daily dose of Levipil.

Please go for a sperm examination. Do not unilaterally stop taking the medicine. A sudden stop can precipitate seizures. Meet your neurologist for an alternative treatment regimen.

Hope I have answered your query. Let me know if I can assist you further.

Take care

Regards,
Dr AJEET SINGH, General & Family Physician
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Do Encorate Chorno / Valparin Effect The Fertility Or Cause Problems To Conceive ?

Hello, The reproductive system can be affected by epilepsy and it s medications, and pituitary hormone abnormalities can be encountered in patients with epilepsy. The mechanism underlying this effect has a close relationship with the alteration of signals in the hypothalamic-pituitary axis. The pituitary gland is responsible for releasing sex hormones, including FSH and LH, whereas the hypothalamus indirectly controls these hormones by releasing the gonadotropin-releasing hormone that targets receptors in the pituitary gland. Valparin treatment does not alter the sex hormone levels in patients with partial and generalized epilepsy. On the other hand, monotherapy negatively affects sperm count, sperm morphology, motility, and sperm functionality. Furthermore, a decrease in the number of functional sperm is associated with an increased daily dose of Levipil. Please go for a sperm examination. Do not unilaterally stop taking the medicine. A sudden stop can precipitate seizures. Meet your neurologist for an alternative treatment regimen. Hope I have answered your query. Let me know if I can assist you further. Take care Regards, Dr AJEET SINGH, General & Family Physician