Hello, Brief Answer: Yes, Spironolactone, Losartan and Carvedilol can cause thigh pain and anger. Detailed Answer: Spironolactone use can cause drowsiness, dizziness, lightheadedness, stomach upset, diarrhea, nausea, vomiting, headache, increased thirst, signs of kidney problems (such as change in the amount of urine), mental/mood changes, unusual fatigue/weakness, muscle spasms, menstrual period changes, breast pain, breast enlargement(gynecomastia) in men, sexual function problems, signs of infection (e.g., fever, persistent sore throat), severe stomach/abdominal pain, persistent nausea/vomiting, vomit that looks like coffee grounds, dark urine, yellowing of the eyes/skin, easy bruising/bleeding. Carvedilol use can cause : dizziness, lightheadedness, drowsiness, diarrhea, impotence, tiredness, very slow heartbeat, severe dizziness, fainting, unusual weakness, signs of kidney problems (such as change in the amount of urine), numbness/tingling of the hands/feet, blue fingers/toes, easy bruising/bleeding, mental/mood changes (such as confusion, depression), seizures. •     Losartan use can cause: dizziness or lightheadedness, a feeling that you might pass out; •     pain or burning when you urinate; •     pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; •     wheezing, chest pain; •     drowsiness, confusion, mood changes, increased thirst, loss of appetite, nausea, and vomiting; •     swelling, weight gain, feeling short of breath, urinating less than usual or not at all; or •     high potassium (slow heart rate, weak pulse, muscle weakness, tingly feeling). Common losartan side effects may include: Cold or flu symptoms such as the stuffy nose, sneezing, sore throat, fever; dry cough; muscle cramps; pain in your legs or back pain, stomach pain, diarrhea; headache, dizziness; tired feeling; sleep problems (insomnia). Hope I have answered your query. Let me know if I can assist you further. Take care Regards, Dr Enton Dore, General & Family Physician