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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Do Cannabis Reduce The Effectiveness Of Ciprofloxacin?

Will smoking cannabis reduce the effectiveness of ciprofloxacin? Ciprofloxacin is metabolized in the liver, so drinking alcohol can reduce the effectiveness of cipro because the liver s workload is being dominated by alcohol and the cipro is not being as efficiently metabolized and distributed by the bloodstream. According to a report on cannabis by the NIH (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC0000/) marijuana is also heavily metabolized by the liver as are most things we ingest. Does this hepatic metabolism of cannabis decrease the bioavailabilty of cipro in the same manner as alcohol?
Mon, 14 Mar 2016
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Addiction Medicine Specialist,  's  Response
no, not significantly. The effect would be to increase the accumulation of it by inhibition of liver metabolism of it. Inhibition of GUT enzymes increases bioavailability. There would be more of it None of which matters to drugs that get in through ways other than the gut! Cipro does not have to be activated by the liver to work (erythromycin requires liver metabolism, is more affected by drugs and alcohol).
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Do Cannabis Reduce The Effectiveness Of Ciprofloxacin?

no, not significantly. The effect would be to increase the accumulation of it by inhibition of liver metabolism of it. Inhibition of GUT enzymes increases bioavailability. There would be more of it None of which matters to drugs that get in through ways other than the gut! Cipro does not have to be activated by the liver to work (erythromycin requires liver metabolism, is more affected by drugs and alcohol).