My wife has had atypical Parkinson s Disease since 2004. She is taking 2 and 1/2 tablets of 25/100 Sinemet tablets via peg tube every 2 and 1/2 hours. She can not talk, walk, stand, she only can move her right hard very slightly for a limited amount of time. She has peg tube for feeding, she is confined to a bed or a recliner. My question is is the Sinemet doing anything at this point of the disease? She is stiff has a board, she starting to had very slight tremors, muscle pain seems to be a problem. I am not sure whether it would be better to reduce the amount of Sinemet, discontinue, or look into a leodupa pump to give her Sinemet.