I have Hereditary Spherocytosis, and I had both my gallbladder and spleen removed at age 9. I am now 40 (I am a female) and I have chronic issues with exhaustion. I would love to excercise and do all of the things that are good for me (I eat a pretty healthy diet) but with the constant exhaustion (to the point that I feel ill most of the time), the thought of doing normal activities is overwhelming, not to mention more strenuous activity. All of my blood work panels seem to come back normal when I visit my family physician. I wonder if this is a common issue with in some people with H.S. My dad had this disorder, and he too seemed to need an inordinate amount of rest.