Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. Breo is a combination of two drugs, one is steroids the other is B2 agonist which opens our airway, the combination of the two drugs is standard management for prophylaxis of airway obstruction in both asthma and COPD, (chronic obstructive pulmonary diease). Anoro is also a combination of two drugs, antimuscarinic and Beta2 agonists, now this combination is also used for COPD but not in asthma because one of the component i.e. antimuscarinic is not used fro asthma. Coming to your concern the antimuscarinic, i.e. one component in Anoro has been reported that it may increase mortality when used in asthma but it does not mean that if it used (either alone or with breo) it would cause death. There is nothing so dreadful. Yes, it s use is not recommended in asthma because in very long terms like after many, many years, it may increase the mortality. What I understand that in asthma, our aim is to control symptoms, if your symptoms are controlled well with breo, there is no need to add any more drugs. I won t personally change it. So I wont advise adding Anoro, if your symptoms are controlled without it. You can talk to your doc regarding this. He may have more idea about your disease. But there is nothing like this that, if your took the two and it would kill some one. Hope I have answered your query. Let me know if I can assist you further.