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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Does Taking Gonal-F Shots And Duphaston During Pregnancy Harm The Unborn Child?

Hi I took 4 injections of GONAL-f® (follitropin alfa) of 150 IU. Now, I am 4 week pregnant. My doctor now prescribed duphastone 10 mg twice aday and asprin 81 mg once aday. I had one miscarriage 6 months ago when I was 7 week pregnant. I had normal pregnancy and delivery 8 y ago. Clear medical history. I am quite concerned about taking these 2 medications together!! Is there any harm to my future baby?? if no, when should I stop them ?? Thanks
Mon, 30 Jul 2018
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General & Family Physician,  's  Response
Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice.

Follitropin Alfa is pregnancy category X according to US FDA: Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits. While Duphaston is allowed to be used in pregnancy with insufficiency of progesterone.

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Does Taking Gonal-F Shots And Duphaston During Pregnancy Harm The Unborn Child?

Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. Follitropin Alfa is pregnancy category X according to US FDA: Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits. While Duphaston is allowed to be used in pregnancy with insufficiency of progesterone. Hope I have answered the question. Let me know if I can assist you further.