Could Pristiq cause skin thinning? I am suddenly experiencing skin thinning. My dosage of Lamictal was increased in December from 200mg to 300mg and my dosage of Pristiq was increased from 50mg to 100mg - for the past three weeks I am experiencing fairly rapid skin thinning where veins are showing up under my eyes and on my legs that were not noticeable before - it's very upsetting and I fear it will continue. My doctor says it cannot be from these two drugs.