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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Does The Levels Of SGOT, SGPT Levels Increase After Taking Interferon Injection For Hep C Treatment?

Please guide me about higher SGOT SGPT level . Before starting Interferon Injection for Hep C Treatment My SGOT SGPT was 160 , 161. But now my viral load (HCV RNA ) is NIL but SGOT SGPT is on heigher side I.E : 198 and 347. Now doctor advice me to take Heptral 400mg twice daily. All other test are Negative like ANA , LKM and ASMA . I want to know that can interferon Injections increases the level of SGOT SGPT. Thanks & Regards Vikram Mittal
Wed, 2 Jan 2013
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Gastroenterologist,  's  Response
Hello, vikram2305,
I am glad that you were started on Interferon injections for treatment
of Hep-C. I am not sure if you were just started on it or have been on
it for a while. You say that your HCV RNA has cleared which is good
news. From that I assume that you have been on treatment for longer
than 12 weeks. When there is active viral replication, you can see enzyme
elevations temporarily but will come down if you have been treated with
proper dosage. If you were treated by single drug like Interferon but
not in combination with Ribavirin, there is a slight chance that you can
have recurrence. That is something to keep in mind.
In that case addition of Ribavarin , weight based dosage would be
helpful. I am glad that immune markers are negative.
Also, I don't know what your Hep-C Genotype is. Response depends
on that as well.
Heptral is pretty much a natural agent and I don't think it is going
to cause any significant side effects. It may give you marginal
benefits.
Hope you can discuss this with your doctor.
I wish you well.
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Does The Levels Of SGOT, SGPT Levels Increase After Taking Interferon Injection For Hep C Treatment?

Hello, vikram2305, I am glad that you were started on Interferon injections for treatment of Hep-C. I am not sure if you were just started on it or have been on it for a while. You say that your HCV RNA has cleared which is good news. From that I assume that you have been on treatment for longer than 12 weeks. When there is active viral replication, you can see enzyme elevations temporarily but will come down if you have been treated with proper dosage. If you were treated by single drug like Interferon but not in combination with Ribavirin, there is a slight chance that you can have recurrence. That is something to keep in mind. In that case addition of Ribavarin , weight based dosage would be helpful. I am glad that immune markers are negative. Also, I don t know what your Hep-C Genotype is. Response depends on that as well. Heptral is pretty much a natural agent and I don t think it is going to cause any significant side effects. It may give you marginal benefits. Hope you can discuss this with your doctor. I wish you well.