Hello sir, The medications such as triamterene and hydrchlorothiazide are diuretics ie they increase the urine output. These medications can cause a rise in creatinine if you are getting over dehydrated. However in view of your age ,and progressive increase in creatinine as you have told,you would need further evaluation for renal dysfunction such as USG abdomen, urine routine and serum electrolytes. Also triamterene can cause increased potassium in the blood in the presence of renal dysfunction. Kindly consult a physician to make adjustments in your medication and also to advise regarding your fluid intake. Hope i was helpful.