Hallow Dear, Siphene is a Clomiphene citrate medicine, used for induction of ovulation. This is an anti-oestrogenic medicine and hence has god adverse effect on the growth of the endometrium. Hence and due to some other reasons also, it has better success in ovulation induction; however success in achieving the pregnancy is lower. Please submit yourself for ovulation monitoring after Siphene. At the time of ovulation, please note size of the follicle(s) and thickening of the uterine lining (endometrium). Follicles between 18 mm to 21 mm size release healthiest eggs and have better pregnancy chances. If the follicles are becoming larger, you may request your doctor to give you Inj. hCG when the size of the follicle(s) is(are) within this range. If the follicles are remaining smaller, you may have to switch over to HMG/hCG combination. The endometrium of thickness between 9 mm and 14 mm is most conducive for implantation of the fertilized ovum. If the endometrium at the time of ovulation is thinner, please do not attempt pregnancy at that cycle. Get your endometrium built up by some oestrogenic preparation first. When it has reached the required thickness or more, then down regulate the oestrogen and attempt pregnancy in the next cycle by induction of ovulation. May be, if Siphene does not work, you may have to switch over to HMG/hCG combination. Also please find out by hysterosalpingography about the patency of your tubes. Husband s semen examination also is needed to find out the quality of the semen. I hope this has provided you preliminary guidelines. For detailed discussion, you may ask me Direct question with all your reports uploaded. Dr. Nishikant Shrotri