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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Have Severe Pain, Depression. Took Lupron, Zoloft. Right Medication?

Hello I am a RN helping my niece with information gathering. She was on Lupron in the past and side effects were horrific but did perserve thru it to no avail. Still having severe pain and she is awaiting a consult with a Pelvic Pain and Endometriosis clinic. In the mean time her Gyne doc gave her a RX for Visanne. She has hx of depression is on zoloft. Can you shed any light on the the similarities with Lupron and this new med.
Sat, 9 Nov 2013
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Psychiatrist,  's  Response
Hello
Welcome to HCM

Lupron is luperolide and it is a drug that is mainly used in various conditions like endometriosis. The drug act on pituitary gland and thus suppresses the GnRH, a hormone of pituitary. Zoloft is sertaline and this is an antidepressant and anti anxiety drug of SSRI group. Both these drugs are different in mechanisms of action and are of different groups.

Visanne is a drug that is introduced recently for long term management of endometriosis. It is a progesterone derivative that is free of serious side effects and it has some androgen action also. It is different from lupron if we consider mechanism of action.

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Have Severe Pain, Depression. Took Lupron, Zoloft. Right Medication?

Hello Welcome to HCM Lupron is luperolide and it is a drug that is mainly used in various conditions like endometriosis. The drug act on pituitary gland and thus suppresses the GnRH, a hormone of pituitary. Zoloft is sertaline and this is an antidepressant and anti anxiety drug of SSRI group. Both these drugs are different in mechanisms of action and are of different groups. Visanne is a drug that is introduced recently for long term management of endometriosis. It is a progesterone derivative that is free of serious side effects and it has some androgen action also. It is different from lupron if we consider mechanism of action. Thanks