Hi, I am currently on Deplin, for which my psychiatrist prescribed for me as I had various depression related symptom. She had me tested for the MTHFR mutations, and I came back positive for MTHFR mutations C667t and A1298C, which led to her recommendation. It seemed to work really well. Recently I have had problems with chronic fatigue, joint pain and may be becoming depressed. I went to my family doctor and he gave me a lecture about Deplin, which he considers to be quack medicine and wants me on an antidepressant. Who should I trust?