Hello! Thank you for the query. Constipations can be a disease itself or it can be a symptom of other disease. If you are 50 or older, colon cancer should be ruled out. If you have any abdominal pains, weight lost, blood in stool, you should also have colonoscopy performed. Lack of intestinal bacterias can be also a reason of constipations. Medicines like Ca-blockers and antidepresants can cause constipations. Thyroid disease can also be the reason. I suggest you to have abdominal ultrasound, blood work, thyroid tests, stool tests performed. You should also start probiotics intake, increase mineral water intake and physical activity. Hope this will help. Regards.