Hello rathoditesh8, advice,-take with full glass of water, do not crush,chew or break, swallow the whole pill, do not consume grape fruit or grape fruit juice, side effect- allergic reaction, hypotension, poor cardic reservse, heart failure, severe aortic stenosis, avoid abrupt withrwal otherwise angina can occured, peripheral oedema, palpitation, tachycardia,flushing,headache,nausea, - avoid following medication (drug interaction)-theophylline, quindine,carbamazepine,phenobabitone, cimetidine,erthomycin,ketacanozole ,itracanazole,rifampicin. contraindication-acute myocardial infarction,cardiogenic shock, acute unstable angina, following disease history taken before start nocardia- kidney, liver,heart, sinus syndrome, aortic stensosis,low blood pressure,coronary artery disease, hope my advice is useful to you,thank you.