Hi MYTHSWAM, Thanks for writing in to Healthcare Magic! If you have uncontrolled diabetes then treatment with insulin or OHA like Gemer-xyz would cause an initial weight gain because they improve the retention of nutrients in the body which was being lost in urine without treatment. Till date there is no reason to believe that Gemer PL2 can cause cancer. Both the regimen you are taking are not appropriate, Gemer should be taken before the main meal of the day once and should be supplemented by some other medicne like metformin in the evening depending on the blood sugar levels. You sould not take Jalra/Gemer in the evening, consult again to a good physician with your current sugar levels and keep a follow up. Side effects of Gemer PL@ are- hypersensitivity, Increased risk of cardiovascular mortality particularly in elderly and debilitated patients, Inappropriate secretion of antidiuretic hormone may be there particularly in patients of C.H.F or hepatic impairment. If you have any further query please let me know I would try to answer it for you. Wish you a great health!