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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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How Can Parkinson S Disease Be Treated?

Hi, I m a 60 year old healthy white male. My father is 93 and has moderate to advanced Parkinsons disease. My Dad s mother had essentail tremors and died at age 93. What are my chances of evenually getting Parkinsons disease? Dad was diagnosed with P about 5 years ago.. Thanks, - Gary -
Tue, 19 Jun 2018
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Internal Medicine Specialist,  's  Response
Hello and Welcome to ‘Ask A Doctor’ service.
I have reviewed your query and here is my advice.

If the rest of your family history is negative for Parkinson's disease then your dad's case is most likely a sporadic one (not related to genetics, at least not to a documented inheritance pattern). Essential tremor is not Parkinson's disease. There are indeed some inheritable cases of Parkinson's disease. Some of them are inherited in an dominant and the rest in a recessive inheritance pattern. Dominant inheritance means that one gene is enough to develop Parkinson's disease and whoever carries that gene will get the disease at some time. Therefore many patients are expected in the family tree as each one hands the gene over to one's descendants. The recessive pattern may hide itself sometimes because two genes (one from each parent) is required for the disease to develop. Some patients (but not as many as in the dominant pattern) are still expected in the same family.Sporadic cases occur without anybody knowing why and they cannot be passed on to the descendants. So if it's a sporadic case, your risk is approximately 1 in 8000 to develop it. Compare this to 50% if your dad had the dominant gene!

Hope I have answered your query. Let me know if I can assist you further.
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How Can Parkinson S Disease Be Treated?

Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. If the rest of your family history is negative for Parkinson s disease then your dad s case is most likely a sporadic one (not related to genetics, at least not to a documented inheritance pattern). Essential tremor is not Parkinson s disease. There are indeed some inheritable cases of Parkinson s disease. Some of them are inherited in an dominant and the rest in a recessive inheritance pattern. Dominant inheritance means that one gene is enough to develop Parkinson s disease and whoever carries that gene will get the disease at some time. Therefore many patients are expected in the family tree as each one hands the gene over to one s descendants. The recessive pattern may hide itself sometimes because two genes (one from each parent) is required for the disease to develop. Some patients (but not as many as in the dominant pattern) are still expected in the same family.Sporadic cases occur without anybody knowing why and they cannot be passed on to the descendants. So if it s a sporadic case, your risk is approximately 1 in 8000 to develop it. Compare this to 50% if your dad had the dominant gene! Hope I have answered your query. Let me know if I can assist you further.