I am a 62 y.o. woman with a h/o MDD and anxiety who has been on Zonegran for atypical migraines for many years. My Doc and I decided to wean me off of the Zonegren (Zonisamide). I went from 300 mg per day to zero over a period of 2 weeks. During that time, and continuing now into the 4th week, my depression very much worsened, I became extremely irritable and angry, had periods of rage and impulsivity, major tearfulness, panic attacks, and nausea. I have just found out that tapering off of Zonegren should be much, much slower. Aside from taking a benzodiazepine to feel better, is there anything else you would advise? I m inclined to just stick it out but I am feeling really miserable. Thank you. Lynn