Hi, I can understand the cause of her depression because of regular bed wetting at night . She is in a hostel with her friends who most likely must be teasing her worsening her condition further . This problem is called as Nocternal Enuresis ( since she is only wetting her bed at night ). Many children suffer from this problem and with every passing year many of them stop doing so.Bed wetting can be due to : - A urinary infection which is a common cause in females more so if the bed wetting is of recent origin. However in your sister s case, she was never dry and you have rightly ruled out Urinary infection as the possible cause -Some children have a very deep sleep and they are able to get up when the bladder is full. This is common in children also with adenoids hypertrophy. -She may be having a small bladder capacity. -Since she is otherwise normal I should not suspect a neurological cause for her problem. It has been seen that medicines used for the problem are not very effective and many children relapse once they are stopped. I will suggest these measures to be tried first : 1. Ask her to stop taking any liquids at 2 hours before going to bed . She should empty her bladder before going to bed and set an alarm after 4 hours to get up and walk to the toilet to pass urine. There are Enuresis alarms available commercially. They can be attached at the diaper area . The alarm starts ringing as soon as the first drop of urine is passed in sleep. This will wake her up . This works like an conditioning reflex. Hope I have answered your query. Let me know if I can assist you further. Take care Regards, Dr. Anil Kumar Bhatnagar