How Does Blood Group Affect Pregnancy?

Hallow Dear, Rh -ve mother and Rh+ve father is a combination where the child may get affected. Usually baby of the first pregnancy is not affected if there is no bleeding during pregnancy. After the first delivery, some blood from the baby leaks into mother s blood and the antibodies to the Rh+ve cells are formed. These antibodies in subsequent pregnancies enter the baby in the uterus and start killing baby s red cells if the baby is Rh+ve. If the mother is not given protection, each subsequent baby gets affected more and more. Therefore after each delivery antigammaglobulin injection needs to be given to prevent the antibody formation in the mother s blood. The first affected baby of second pregnancy develops severe jaundice due to destruction of red cells in large number. Such baby s require exchange blood transfusion. Subsequent baby s are affected earlier and earlier while in utero. The extent of damage in the mother s blood is assessed by Indirect Coomb s test which measures the titre of the Rh antibodies in the mothers blood. Depending upon the titre, the mother is given injection of Rh antigammaglobulin and the baby may be given blood transfusion while in utero. I think I have simplified the complicated topic for your understanding to the most. If you need detailed information about this, you may ask me Direct question by going to my profile. Dr. Nishikant Shrotri