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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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How Long Does Nitroglycerin Sublingual Stay In System?

How long does Nitroglycerin sublingual stay in my system. I took two 4 mg tabs approx 10 minutes apart. Having some swelling in ankles and headache (it has eased off). However, still feeling the tingling and swelling of ankles. Took 2 Advil for headache.
Mon, 2 Mar 2015
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General & Family Physician,  's  Response
Thanks for being concerned about your health!

You mention having taken two nitroglycerin 4 mg sublingual tablets, ten minutes apart. Nitroglycerin usually comes in a dosage of 0.4 mg tablets, that are supposed to be taken at 5 minute intervals, without taking more than 3 tablets in a session.

Please check your tablet package, if the "4 mg" as you've written is a typo, then I'd say that half the drug is destroyed in the body in about four minutes and the side effects that you're worried about, such as ankle swelling and tingling should not last for more than an hour.

If you have actually taken two 4 mg tablets 10 minutes apart, then I'd say that you should consult a physician immediately for further assistance.

Advil, also known as Ibuprofen can be taken for headaches, and I'd rather you take Tylenol (Paracetamol) for the same, as it will be easier on your stomach in the long term.
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How Long Does Nitroglycerin Sublingual Stay In System?

Thanks for being concerned about your health! You mention having taken two nitroglycerin 4 mg sublingual tablets, ten minutes apart. Nitroglycerin usually comes in a dosage of 0.4 mg tablets, that are supposed to be taken at 5 minute intervals, without taking more than 3 tablets in a session. Please check your tablet package, if the 4 mg as you ve written is a typo, then I d say that half the drug is destroyed in the body in about four minutes and the side effects that you re worried about, such as ankle swelling and tingling should not last for more than an hour. If you have actually taken two 4 mg tablets 10 minutes apart, then I d say that you should consult a physician immediately for further assistance. Advil, also known as Ibuprofen can be taken for headaches, and I d rather you take Tylenol (Paracetamol) for the same, as it will be easier on your stomach in the long term.