Hello, Thanks for choosing health care magic for posting your query. I have gone through your question in detail and I can understand what you are going through. Estrace is estradiol cream which is an hormonal preparation and this can cause anxiety as an adverse effect. The temporal relationship that you have noted with the usage of drug and appearance of anxiety further supports the possibility. Ones you are off the medications, it may take 1-2 weeks for the drug to go out of your system completely. Your anxiety will improve without any drugs, but you need to give it some time. If it is very disabling then you may take Propranolol for anxiety. Hope I am able to answer your concerns. If you have any further query, I would be glad to help you. In future if you wish to contact me directly, you can use the below mentioned link: bit.ly/dr-srikanth-reddy Wish you good health, Kind regards Dr. Srikanth Reddy M.D.