Hello, Thanks for posting your query on Healthcare Magic... * Brief Answer: your brother blood pressure needs more control.multiple drug strategy may be needed in some cases to control blood pressure. *Explanation: My opinion is that in your brother case , he is managed perfectly, first his doctors tried to exclude other causes of secondary hypertension by investigations , then started management. normally we as doctors start with one or two drugs and escalate accordingly , increase the dose or shift to other medication. your brother blood pressure still high though, 160/90 is a high number if multiple blood pressure readings support that . lower limb edema may be a side effect of Amlong, heart rate is normal , nothing to worry about. I suggest my patients the following : add a diuretic in resistant cases of hypertension, Lasix or another diuretic . that would help a lot. also complete the investigations to exclude causes like pheochromocytoma or other endocrinal causes. The information provided by you is not sufficient to provide a good opinion. If someone comes to me with this condition I would ask them about other diseases like diabetes .also if a smoking history is present.lipid profile is needed to assess hyperlipidemia and atherosclerosis *Conclusion: I suggest you ask your brother physician about benefit of adding diuretic to the medications .or decrease the dose of Amlong. If you have any further questions I will be happy to help, If not, you can close the discussion and rate the answer. Wish your brother good health.