Hi & Welcome. This medicine can cause throat irritation if its capsule is broken or chewed. Therefore, Lymecycline capsules should always be taken with a glass of water. Try to avoid taking the capsules just before lying down or at bedtime. Since food, milk or other dairy products, certain medications like antacid, calcium, iron, aluminium may reduce its absorption of Limecycline from the intestines hence should not be taken together at the same time. If at all take them at least two hours before Lymecycline capsules or two hours after. Hope to have answered your query. A feedback is appreciated.