In February of 2013, my 60 mg Simvastatin was changed to 40 mg Lipitor (Chol. 200; Trigl. 49; LDL 104), which brought the lipids down to (161; 69; 77). Because in 2013 LDL was felt to be best I am interested in the raise of bili and alkaline p tase that took place over that period of time. In February 2013: total bili was 0.7; I don t have the alk. p tase level. In September 2013: total bili was 1.4 (upper limit here is 1.3) with 85 alk. p tase. In March 2014, total bili was 1.6 with an alk. p tase of 120 (upper limit of normal is 126). My question is, how soon one should recheck the liver function tests, and when does one start thinking about a possible obstructive process vs. drug effect? Thank you for answering the questions.