I had a total hysterectomy at age 38, I have been taking premerin for 20 yrs. I am very concerned about health risks. I have tried a few times to get off this medication. having severe mood swings, crying jags, anxiety, headaches, severe dry eyes, mental confusion, other symptoms on a reduced dosage. after months of those symptoms I went back to the 1.25 mg. dosage. and all those symptoms stopped. it works, but is very expensive. I don t want to take it. is there any alternatives?