Hi dear user I have gone through your question. I can understand your concern. In advanced stage of renal disease there is severe water-sodium retention,wich may cause blisters when the fluid becomes trapped under your skin,but in my opinion your wife is not in End-stage renal disease. My advice is to consult a nephrologist in your area because you need to have an exact diagnose and treatement for your wife s renal condition. She need also to take iron treatement for anemia and a hypocaloric diet because she has morbid obesity. Hope I have answered your question. If you have any further questions I will be happy to help. Thank you for using HCM.. Wish you good health.