There are probably a couple different things going on here. You could have taken too much suppository which will take a couple day to wear off. You could also have caused some inflammation in the rectum from suppository which can cause loose/watery stools. You could have worsening of your MS. You could have a viral or bacterial diarrheal illness which can takes days to months to get better. Or you could have developed inflammatory bowel disease. Watery diarrhea can be life-threatening if it is prolonged without adequate treatment. Majority of the time it causes electrolyte imbalance and dehydration. I can not tell you if these symptoms will ever stop, but I know your doctor can prescribe medications to help slow the stool. I would recommend: -routine screening blood work and stool studies with your primary care doctors -You may need a colonoscopy for further evaluation. -You can try probiotics. -BRAT diet - bananas, rice, applesauce, toast helps. -avoid coffee, alcohol, diary products, red meats, and seasoned foods. -if work up is unremarkable, your doctor can prescribe you anti-diarrheal medications.